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一個心理變態的狂徒，專向患有頑疾的病人下毒手，首先遇害者是一位患有胃病多年的落難佬倌，跟著是患有乳癌的魚蛋妹，簡探員伊雷長期患有風濕病的母親，亦不幸遇害，情況使警方束手無策，三個疑犯分別是魚蛋妹的男朋友；有醫生資格卻不獲發牌的倒霉醫生及對醫學有濃厚興趣的小販，但警方經過細心調查下，還是查不出結果，就在探員伊雷往醫院切除痔瘡時，卻在手術床上遇上兇手，結果……。Four egocentric friends who meijubar.net run a neighborhood Irish pub in Philadelphia try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.。